Kevin Leehey, M.D.
1200 North El Dorado Place
Building H, Suite 800
Tucson, AZ 85715
(520) 296-4280


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Group Main Use Medication
Form Dose Schedule Dose Range Most Common Side Effects for Group Pros for Group Cautions for Group

(depression, anxiety,OCD, panic)

10 mg
20 mg
40 mg

tablet, scored
10 mg

20 mg/5cc

usually a.m. Child: 5-20 mg
Adoles: 10-40 mg
Adults: 20-80 mg

Increased energy which may be pleasasnt or feel like anxiety, agitation or irritabliity. Zoloft and Paxil may sedate (rarely Prozac), Luvox most likely to sedate.

Decreased appetite, sometimes with nausea. Less
if taken with food.
25-30% experience
decreased sex drive or

Less common: increased urinary frequency, dry mouth or sweating, vivid dreams.
Some migraine increase with Prozac.
Once a day for Prozac, Zoloft and Paxil. Very good safety profile.

No labs, no EKG typically needed. No heart side-effects. Few significant interactions except increases Seldane, Hismanal and tricyclic antidepressant blood levels.

Excellent for mild, moderate and severe depressions and anxiety disorders including panic, mixed, obsessive compulsive, post traumatic stress and atypical types.

Research does not show significant increased suicide or homicide risk. Very low risk in overdose. Reportedly, low risk in pregnancy and breast feeding.

SRI side effects (as with most meds) often lessen with time.
Any SRI, especially Prozac, may agitate if excess energy occurs.

Switch to evening if sedation occurs. Takes 1-3 weeks to begin to help and 1-3 months for maximum effect.

Avoid combination or overlap with MAOI.

Celexa became available in US Sept.98, although it has been in use in Europe substantially since about 1990.
tablet, scored
25 mg
50 mg
100 mg
usually a.m., evening if sedation
Child: 25-50 mg
Adoles: 50-100 mg
Adult: 50-200 mg
tablet, scored
10 mg
20 mg
30 mg
40 mg


usually a.m.,evening if sedation
Child: 5-30 mg
Adoles: 10-60 mg
Adult: 10-80 mg

tablet, scored
25 mg
50 mg
100 mg
often twice a day evening if sedation
Child: 25-200 mg
Adoles: 50-300 mg
Adult: 100-300 mg
tablet, scored
usually a.m., evening if sedation Child: 5-20mg
Adoles: 10-40mg
Adult: 10-80mg
similar to other SRI, but may be less frequent
tablet, scored
25 mg
37.5 mg
75 mg
100 mg

xr(extended release)
37.5 mg
75 mg
150 mg
2 or 3 times a day

XR once a day
Child: 18 3/4-200 mg
Adoles: 75-300 mg
Adult: 150-375 mg
Same as other SRI Effexor increases both serotonin and norepinephrine thus affecting two important neurotransmitter systems, unlike other SRI's. May help attention deficit hyperactivity disorder (ADHD) Slight risk increased blood pressure at doses over 200 mg total a day. (less than 5% chance.)

Same as above

All these medications should be taken 7 days a week to be effective. Simultaneous use of alcohol or cigarettes and especially street drugs should be avoided. All antidepressants may increase mania risk in persons with Bipolar (manic-depressive) disorder. All medications should be avoided if possible in pregnancy. This chart is intended to be a summary guide, not a full and complete list.

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